took her an extra day to think of a caption that wasn’t just “LOOK AT MY ASS” and i respect that
Cool new paper in Cell that ties together two fundamentals of cancer biology: cancer cells have high levels of lactate (due to the Warburg effect), and almost always find a way to inactivate the cell's best tumour suppressor, p53
Zong et al. found that lactate, from the microenvironment, is transferred onto p53 as a post-translational modification - this inhibits p53 by stopping it from binding to DNA
In a mouse model of colon cancer, β-alanine (an amino acid and sports supplement, which blocks p53 lactylation) boosts p53 function and prolongs mouse survival - especially when combined with the chemotherapeutic drug, doxorubicin:
We Are on a Journey
Wherever you are, and whoever you maybe, there is one thing in which you and I are just alike at this moment, and in all the moments of our existence....